Figure 3: AKR enzymatic activity and AKR1A1 gene expression in human (IMAGE)

Tokyo Metropolitan Institute of Medical Science

Figure 3: AKR enzymatic activity and AKR1A1 gene expression in human

Caption

(A) The enzymatic activities of AKR in the red blood cells of six patients with schizophrenia (SCZ#1 to #4 with the c.753G>A variant and SCZ#5 and #6 without the variant) and two control subjects (CON#1 and #2 without the variant) were examined. The enzymatic activity in patients with GA was slightly lower than that in subjects with GG. (B) The AKR1A1 mRNA expression in five subjects (SCZ#1, SCZ#3, SCZ#4, SCZ#6, and CON#2) was quantified by qPCR. The mRNA expression of AKR1A1 with c.753 GA alleles was decreased to approximately 50% compared to that with c.753 GG.

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