Strained and relaxed conformations of uracil bound to wild type and inactive mutant enzymes, respectively (IMAGE)
Caption
Researchers pointed out that the identified transformation mechanism is able to convert uridine in any RNA that fits well to the guide RNA of the box H/ACA pseudouridine synthase, and the structure of the guide RNA can vary to a large extent. Thus, engineered guide RNAs that can associate with the pseudouridine synthase complex may be applied to facilitate the endogenous pseudouridylation of nearly any substrate. This suggests the opportunity of programmable RNA edition for a wide range of RNAs and therapeutics for gene lesion related diseases.
Credit
Illustration made by: Dora Karancsiné Menyhard
Usage Restrictions
Credit must be given
License
Original content