Structure of Respiratory Complex I (IMAGE) University of Groningen Caption This picture shows the structure of Respiratory Complex I. Mutation in the section that is located in the inner membrane that block proton pumps will cause acidification of the cell in the case of metabolic disturbance. This can lead to a shutdown of protein-mediated process and protein synthesis, which in turn make the cell tolerant for certain antimicrobials. Credit Bram van den Bergh, KU Leuven Usage Restrictions Credit must be given to the creator. Adaptations must be shared under the same terms. License CC BY-SA Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.