PINK1 and Parkinson's disease (IMAGE)
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PINK1 (pink) PINK1 on the mitochondrial membrane (green). Researchers at WEHI in Melbourne, Australia, have solved a decade-long mystery about a critical protein linked to Parkinson’s disease that could help to fast-track treatments for the incurable disease. The research, published in Nature, has for the first time produced a ‘live action’ view of the protein, called PINK1, in exquisite molecular detail. The discovery explains how the protein is activated in the cell, where it is responsible for initiating the removal and replacement of damaged mitochondria. When the protein is not working correctly, it can starve brain cells of energy, causing them to malfunction and – in the long term – die, as happens to dopamine-producing cells in Parkinson’s disease. The discovery is the culmination of a project spanning eight years and provides the first detailed blueprint for the discovery and development of therapeutic agents that could help to slow or even stop the progression of Parkinson’s disease. Led by PhD student Mr Zhong Yan Gan and Professor David Komander, the multidisciplinary team at WEHI used innovative cryo-electron microscopy facilities and research to make the discovery.
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Etsuko Uno/WEHI.TV
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