Figure 2. Diagram summarizing the mechanism by which miR-766-5p reduces the activity of super-enhancers in cancer cells. (IMAGE)

Tokyo Medical and Dental University

Figure 2. Diagram summarizing the mechanism by which miR-766-5p reduces the activity of super-enhancers in cancer cells.

Caption

miR-766-5p downregulated the levels of H3K27Ac at super-enhancer regions by targeting acetyl transferase CBP. H3K27Ac is required for enhancer activation and BRD4 binds to active enhancers to drive transcription. As miR-766-5p concurrently targets CBP and BRD4 or BRD4-NUT, miR-766-5p may efficiently suppress the expression of SE-marked genes such as MYC in cancer cells.

Credit

Department of Molecular Cytogenetics, TMDU

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