DNA Demethylation and Splicing (IMAGE) Niigata University Caption Demethylation of DNA in the TDP-43 autoregulatory region using dCas9-TET1 fusion system attenuates alternative splicing involved in autoregulation and increases TDP-43 gene expression. Credit Niigata University Usage Restrictions The image may only be used with appropriate caption or credit. License Original content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.