Age-related Demethylation (IMAGE) Niigata University Caption In the human motor cortex, this DNA region demethylates with age and TDP-43 gene expression increases. Accelerated demethylation of this DNA region is associated with age of onset of ALS. Credit Niigata University Usage Restrictions The image may only be used with appropriate caption or credit. License Original content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.