Mechanism regulating the production of new actin filaments (IMAGE)
Caption
Up: Binding of actin to the nucleation promoting factor stimulates the nucleation process starts (1). If the end of the actin filament close to the membrane binds to the nucleation promoting factor, the nucleation process is disrupted (2). This is prevented by binding of the actin filament by the capping protein. Down: If the tentacle of the capping protein on the actin filament is removed, it unintentionally binds to the nucleation factor and disrupts the nucleation process (3). This strengthens the tethering between the actin network and the membrane and decreases the network growth velocity.
Credit
Max Planck Institute of Molecular Physiology
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