Figure 2 Molecular model showing binding between CpG DNA and CXCL14. (IMAGE)

Tokyo Metropolitan Institute of Medical Science

Figure 2 Molecular model showing binding between CpG DNA and CXCL14.

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Simulations revealed that the phosphate group of CpG DNA is recognized by amino acids R7, K8, and R11 of CXCL14, which reside at the N-terminus, and by amino acids S57 and R60, which reside at the C-terminus. These results suggest that the amino acids at the N-terminal and C-terminal ends work co-operatively.

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