Oncotarget Podcast: ATM Inhibition Overcomes Resistance to Histone Deacetylase Inhibitor (AUDIO)
Caption
The cover for issue 37 of Oncotarget features Figure 7, "The combination of romidepsin and KU60019 is synergistic in a xenograft model of MCL," by Scotto, et al. which reported that the antiproliferative effect induced by histone deactylase inhibitors is associated with the up-regulated expression of the cyclin-dependent kinase inhibitor p21. Paradoxically, the increased expression of p21 correlates with a reduced cell killing to the drug.
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Correspondence to - Owen A. O'Connor - owenaoconnor@gmail.com
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