Mechanism of Inhibition of Dopamine Neuronal Cell Death by Liquiritigenin (IMAGE)

DGIST (Daegu Gyeongbuk Institute of Science and Technology)

Mechanism of Inhibition of Dopamine Neuronal Cell Death by Liquiritigenin

Caption

Mechanism of inhibition of dopamine neuronal cell death by Liquiritigenin : When mitochondrial function is impaired by active oxygen, MPP +, rotenone, 6-OHDA, and α-synuclein fibril, the activation of PARP1 causes DNA damage. In addition, the accumulation of the substrate AIMP2 of the parkin protein induces hyperactivity of PARP1 and results in cell death of dopaminergic neurons. Liquiritigenin inhibits dopamine neuronal cell death in Parkinson's disease as it binds to the estrogen receptor beta and is transported to the nucleus, stimulates transcription of RNF146 and controls the activation of PARP1.

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Daegu Gyeongbuk Institute of Science and Technology (DGIST)

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