Figure 2: Deficiency of the COMMD3/8 Complex Impairs B Cell Migration and Humoral Immune Responses (IMAGE)

Osaka University

Figure 2: Deficiency of the COMMD3/8 Complex Impairs B Cell Migration and Humoral Immune Responses

Caption

(A) COMMD8-deficient (Commd8Δ) activated B cells (NP-PE+, green) show impaired migration toward the outer region of B cell follicles (IgD+ areas, red) at 3 h after immunization. (B and C) B cell-specific COMMD8-deficient mice show severe defects in the antibody response (B) and generation of germinal center B cells (GL7+, red) (C). CD4 (blue) was labeled to define T cell areas in the spleen. **P < 0.01, paired t-test. Scale bars, 200 μm.

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Osaka University

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