Figure 1: Proposed Role of the COMMD3/8 Complex in Chemoattractant Receptor Signaling (IMAGE)

Osaka University

Figure 1: Proposed Role of the COMMD3/8 Complex in Chemoattractant Receptor Signaling

Caption

The COMMD3/8 complex recruits GRK6 to chemoattractant receptors through a stepwise mechanism: (i) the C-terminal tail of the activated receptor is phosphorylated by GRK2 and GRK3. (ii) the COMMD3/8 complex is associated with the receptor tail through electrostatic interactions with the phosphorylated residues. (iii) GRK6 is recruited to the receptor through the interaction with the COMMD3/8 complex and phosphorylates the C-terminal tail.

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Osaka University

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