Anti-Parasite Compound Controls Cryptosporidium Infection in Mice (2 of 4) (IMAGE)

American Association for the Advancement of Science (AAAS)

Anti-Parasite Compound Controls Cryptosporidium Infection in Mice (2 of 4)

Caption

Three-dimensional crystal structure of the target CPSF3 protein (in blue) bound to the AN3661 inhibitor (in yellow) with a scanning electron micrograph background of Cryptosporidium infecting the ileum of an immunocompromised mouse. This material relates to a paper that appeared in the Nov. 6, 2019, issue of Science Translational Medicine, published by AAAS. The paper, by C. Swale at University Grenoble Alpes in Grenoble, France; and colleagues was titled, "Metal-captured inhibition of pre-mRNA processing activity by CPSF3 controls Cryptosporidium infection."

Credit

[Credit: C. Swale, F. Laurent, and S. Georgeault]

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