Why Acidosis Can Cause Brain Damage in Newborns with Jaundice (1 of 2) (IMAGE)

American Association for the Advancement of Science (AAAS)

Why Acidosis Can Cause Brain Damage in Newborns with Jaundice (1 of 2)

Caption

Mouse brain is stained blue by Evans blue, a dye that cannot permeate into brain tissue when the blood-brain barrier (BBB) is intact. This image shows that hypoxia-induced acidosis can lead to a compromised BBB and penetration of dye into brain tissue. This material relates to a paper that appeared in the Feb. 12, 2020, issue of Science Translational Medicine, published by AAAS. The paper, by K. Lai at Sixth People's Hospital of Shanghai in Shanghai, China; and colleagues was titled, "Bilirubin enhances the activity of ASIC channels to exacerbate neurotoxicity in neonatal hyperbilirubinemia in mice."

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[Credit: Sixth people's hospital of Shanghai, department of photography]

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