Direct catalytic asymmetric introduction of non-protected amino groups at the α-position of carbonyl compounds (IMAGE)

Institute of Transformative Bio-Molecules (ITbM), Nagoya University

Direct catalytic asymmetric introduction of non-protected amino groups at the α-position of carbonyl compounds

Caption

The hydroxylamine is converted into a reactive intermediate in the presence of trichloroacetonitrile. The chiral 1,2,3-triazolium salt, a unique phase transfer catalyst developed by Ooi's group, enables stereoselective carbon-nitrogen bond formation by the generation of chiral enolates of carbonyl compounds.

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ITbM, Nagoya University

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