Telomeric Elongation Process, CNIO (IMAGE)

Centro Nacional de Investigaciones Oncológicas (CNIO)

Telomeric Elongation Process, CNIO

Caption

Scheme representing the telomeric elongation process associated with the cell division of pluripotent cells and the generation of animals with hyper-long telomeres. Mouse embryonic stem cells are obtained and cultured for a controlled number of cell divisions to allow telomeric elongation in the absence of any genetic manipulation. Upon telomere elongation, pluripotent cells with hyper-long telomeres are introduced into a recipient embryo with normal cells, thus generating a chimera with cells of different origins (normal and hyper-long telomere embryonic stem cells). These chimeric embryos are re-implanted in a mouse for the generation of mice in which 100% of their cells are derived from embryonic cells with hyper-long telomeres.

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CNIO

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