A Schematic Model for the Involvement of TRPV2 in Thermogenesis in Brown Adipose Tissue (IMAGE)

National Institutes of Natural Sciences

A Schematic Model for the Involvement of TRPV2 in Thermogenesis in Brown Adipose Tissue

Caption

BAT thermogenesis is triggered by the release of norepinephrine from the sympathetic nerve terminals which stimulates β3-adrenergic receptors, turning on a cascade of intracellular events including production of UCP1, a protein involved in thermogenesis. TRPV2-mediated calcium influx could regulate the thermogenic gene expression. At room temperature, the sympathetic nerve activity is kept in a resting condition and UCP1 expression level is low which causes less heat production. On the other hand, when cold temperature is detected by peripheral temperature-sensitive nerve endings, sympathetic nervous system could be activated, which leads to norepinephrine release from the sympathetic nerves and activation of β3-adrenergic receptors. Subsequently, TRPV2 expression is up-regulated and more calcium is influxed via TRPV2, facilitating UCP1 expression and heat production. BAT: brown adipose tissue; FFA: free fatty acids; SNS: sympathetic nervous system; β3ADR: β3-adrenergic receptor; TG: triglyceride; UCP1: uncoupling protein 1.

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