NOTCH2NL Copy Number (IMAGE)

Howard Hughes Medical Institute

NOTCH2NL Copy Number

Caption

On the long arm of chromosome 1, deleting a copy of the gene NOTCH2NL (green), can result in microcephaly, or abnormally small brain size (left). Duplicating these genes can have the reverse effect: macrocephaly, or oversized brains (right).

Credit

I. Fiddes et al./Cell 2018

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