Summary of this Work (IMAGE)

Osaka University

Summary of this Work

Caption

The Mis18 complex including KNL2/M18BP1 associates with CENP-A nucleosomes (Old CENP-A) in centromeres. Pre-deposit CENP-A with H4 and HJURP (New CENP-A) recognizes the Mis18 complex on centromeres. Then, new CENP-A is correctly deposited into centromeres (CENP-A loading). This process explains how CENP-A is correctly deposited into centromeres.

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Osaka University

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