Remodelin to the Rescue of Nuclear Defects? (2 of 3) (IMAGE)

American Association for the Advancement of Science (AAAS)

Remodelin to the Rescue of Nuclear Defects? (2 of 3)

Caption

High-resolution microscopy pictures show nuclear shape rescue of cells depleted for Lamin A/C by siRNA upon Remodelin treatment. A non-treated cell is shown on the left and a Remodelin-treated cell is shown on the right. The nucleus is visualized in blue by DAPI. The nucleoli are visualized in green by NAT10 staining. This image relates to a paper that appeared in 2 May, 2014, issue of Science, published by AAAS. The paper, by Delphine Larrieu at the Wellcome Trust/Cancer Research UK (CRUK) Gurdon Institute in Cambridge, UK, and colleagues was titled, "Chemical Inhibition of NAT10 Corrects Defects of Laminopathic Cells."

Credit

[Image courtesy of Delphine Larrieu]

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