Figure 1 Histone H3K27 Acetylation Precedes Active Transcription during Zygotic Genome Activation (IMAGE)

Tokyo Institute of Technology

Figure 1 Histone H3K27 Acetylation Precedes Active Transcription during Zygotic Genome Activation

Caption

Fab-based imaging to monitor the dynamics of active transcription and histone modifications during ZGA in living zebrafish embryos revealed spatiotemporal coordination within single nuclei, where H3K27 acetylation was concentrated at distinct foci on the miR-430 gene cluster prior to its transcription. These observations, together with inhibitor assays, suggest that H3K27ac precedes active transcription during ZGA.

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Tokyo Tech

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