Cellular Senescence and Body Aging (IMAGE)
Caption
(Top) In cellular senescence, proliferative genes are repressed and senescence genes are activated. This gene regulation takes place through modifications of the epigenome, and may be thought of as a program for cellular senescence.
(Bottom) Individual aging of the entire body is recorded in the epigenome of many cells and is caused by the random actions of many environmental factors.
Senescent cells are an important component of the aging body because they lose their ability to proliferate and secrete a variety of proteins that promote chronic inflammation and cancer development throughout the body.
Credit
Professor Mitsuyoshi Nakao
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