Phenotypic Variations in Cellular Senescence (IMAGE)

Kumamoto University

Phenotypic Variations in Cellular Senescence

Caption

There are at least four states of cellular senescence based on the characteristics of the senescence-associated secretory phenotype (SASP): (1) initiation (growth arrest), (2) early (anti-inflammatory), (3) full (increased inflammation and metabolism), and (4) late (decreased inflammation and metabolism).

Coordination between intracellular metabolism and epigenomic remodeling shapes the phenotypic variation of cellular senescence.

Credit

Professor Mitsuyoshi Nakao

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Reprinted from <a href="https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(20)30170-7">Trends in Cell Biology, Nakao, M., Tanaka, H., & Koga, T, Cellular Senescence Variation by Metabolic and Epigenomic Remodeling, (2020)</a> with permission from Elsevier.

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