Tiny Particles Keeps Artery Plaques in Check in Mouse Models of Atherosclerosis (2 of 2) (IMAGE)

American Association for the Advancement of Science (AAAS)

Tiny Particles Keeps Artery Plaques in Check in Mouse Models of Atherosclerosis (2 of 2)

Caption

Tao et al. provided proof-of-principle evidence for the use of targeted siRNA nanoparticles (green color particles) to silence a plaque-destabilizing gene in these macrophages (red color cells). The image depicts targeted nanoparticles can specifically active lesional macrophages, promote efferocytosis, and inhibit atherosclerotic plaque necrosis (blue-violet color substance). This material relates to a paper that appeared in the Jul. 22, 2020, issue of Science Translational Medicine, published by AAAS. The paper, by W. Tao at Brigham and Women's Hospital in Boston, MA; and colleagues was titled, "siRNA nanoparticles targeting CaMKIIγ in lesional macrophages improve atherosclerotic plaque stability in mice."

Credit

[Credit: Wei Tao]

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