Figure 1. CD86 serves a marker to identify hematopoietic progenitors under biological stresses (IMAGE)

Tokyo Medical and Dental University

Figure 1. CD86 serves a marker to identify hematopoietic progenitors under biological stresses

Caption

Both Sca-1 and CD86 are expressed on hematopoietic stem progenitor cells (HSPCs) at steady state. However, under biological stresses, such as infection and inflammation, myeloid progenitors acquire Sca-1 expression, which makes the identification of HSPCs impossible. Because CD86 expression remains unchanged even under the stresses, CD86-based analysis enables observation of bona fide hematopoietic responses.

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Department of Biodefense Research, Medical Research Institute, TMDU

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