A Novel Role For A C-terminal Region (Amino Acids 2042 And 2061) That Regulates Fast Release (IMAGE)

Max Planck Florida Institute for Neuroscience

A Novel Role For A C-terminal Region (Amino Acids 2042 And 2061) That Regulates Fast Release

Caption

A, Cartoon depicting truncated regions in our CaV2.1 α1 deletion mutants including the binding sites for CaV β4, CASK, RBP, PXXP, RIM1/2 and Mint-1 along with the effects of C-terminal truncations on ICa. B, Averaged traces of RRP and total releasable pool measurements from mice expressing Cre + full transcript CaV2.1 rescue (grey), Δ2365-2368 (cyan), Δ2212-2368 (yellow), Δ2061-2368 (purple), Δ2042-2368 (green) or Δ2016-2368 (blue). ICa (top) and EPSCs (bottom) triggered by 3ms and 30ms pulses, plotted on top of each other (n=10 for each group, except for Δ2212-2368: n=8).

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Max Planck Florida Institute for Neuroscience

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