3-D Structures of Brinzolamide and Dorzolamide (IMAGE)

DOE/Oak Ridge National Laboratory

3-D Structures of Brinzolamide and Dorzolamide

Caption

Three-dimensional structures of the clinical drugs brinzolamide (BZM, left) and dorzolamide (DZM, right) as observed in the hCA II active site. The red arrow shows the amino groups of the drugs: in BZM, the nitrogen atom (in blue) is not protonated and thus not charged; in DZM, the nitrogen atom has accepted an extra proton and thus is positively charged.

Credit

(ORNL/Andrey Kovalevsky)

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Source to: ORNL/Andrey Kovalevsky

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