Active Site of hCA II (IMAGE)

DOE/Oak Ridge National Laboratory

Active Site of hCA II

Caption

This image shows the active site of hCA II. The active site is flanked by hydrophilic (violet) and hydrophobic (green) binding pockets that can be used to design specific drugs targeting cancer-associated hCAs. Five clinical drugs are shown superimposed in the hCA II active site, based on room-temperature neutron structures.

Credit

(ORNL/Andrey Kovalevsky)

Usage Restrictions

Source to: ORNL/Andrey Kovalevsky

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