Figure 2 Endothelial-to-adipocyte fatty acid transport determines metabolic health. (IMAGE)

Institute for Basic Science

Figure 2 Endothelial-to-adipocyte fatty acid transport determines metabolic health.

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Angpt2 produced from fat cells interacts with its receptor integrin α5β1 to drive fatty acid transporters (CD36 and FATP3) and ensures normal circulating fat. If this Angpt2-integrin α5β1 signaling does not work, defects in buffering capacity of fat tissue lead to fat spillover into the liver and muscle, convert brown fat to white fat, and consequently result in defects in metabolic health.

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