Exposure to leaking metabolic enzymes promotes proliferation of satellite cells after muscle injury (IMAGE)

Kumamoto University

Exposure to leaking metabolic enzymes promotes proliferation of satellite cells after muscle injury

Caption

<p>In a mouse muscle damage model, GAPDH recombinant protein was injected into the tibialis anterior muscle 24 hours before muscle damage was induced by drug injection (DMDF group). Phosphate buffered saline (PBS) was administered to the control group. The number of EdU-positive cells increased in the DMDF group compared to the control group, as assessed by immunohistochemical staining of muscle tissue 48 hours after muscle injury. </p> <p>PAX7: satellite cell marker; EdU: proliferation marker; yellow arrows: proliferating satellite cells; *p < 0.05 </p>

Credit

Associate Professor Yusuke Ono

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<p>Top adapted from Fig. 7(G) and bottom adapted from Fig. 7(H) of <a href="https://www.sciencedirect.com/science/article/pii/S2213671120303337">Tsuchiya et.al. Stem Cell Reports, 2020</a>. Modifications (text added for clarification) have been made by the original author for use in this release. </p> <p>This image is made available under the terms of <a href="https://creativecommons.org/licenses/by-nc-nd/4.0/">CC BY-NC-ND 4.0</a>. Any further distribution of this work must follow the terms of this license. </p>

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