Hypoglycemic effect of DNP peptide synthesized from L- and D-amino acids and zinc insulin (IMAGE)

Kumamoto University

Hypoglycemic effect of DNP peptide synthesized from L- and D-amino acids and zinc insulin

Caption

<p>Left: blood glucose levels continued to decrease from 15 to 60 minutes after administration. This decrease in blood glucose levels persisted until at least 120 minutes after administration. </p> <p>Right: A decrease in blood glucose levels was observed 15 minutes after oral administration, and the hypoglycemic effect persisted until 120 minutes after administration. </p>

Credit

Associate Professor Shingo Ito

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Reprinted with permission from <a href="https://pubs.acs.org/doi/full/10.1021/acs.molpharmaceut.0c01010" target="_blank"> Ito, S., Torii, Y., Chikamatsu, S., Harada, T., Yamaguchi, S., Ogata, S., ... Ohtsuki, S. (2021). Oral Coadministration of Zn-Insulin with d-Form Small Intestine-Permeable Cyclic Peptide Enhances Its Blood Glucose-Lowering Effect in Mice. Molecular Pharmaceutics. doi:10.1021/acs.molpharmaceut.0c01010</a>. Copyright 2021 American Chemical Society.

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