Host and Microbiota Conflict (IMAGE)

Arizona State University

Host and Microbiota Conflict

Caption

Dangerous escalation may result from unresolved conflict between host and microbiota, fueled by a competitive arms race between host and microbiota. Immune resistance is triggered by microbial signals associated with invasion or other harm to the host. Inflammation, in turn, causes increased microbial virulence gene expression. Positive feedback perpetuating escalating conflict can result in increasing costs and a negative outcome for both partners.

Credit

Graphic: Jason Drees for the Biodesign Institute

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