Kidney Infection (IMAGE)

Centro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.)

Kidney Infection

Caption

Kidney infection with the fungal pathogen Candida albicans causes tissue damage. In wild-type mice, DNGR-1 expressed on dendritic cells detects this injury, and this triggers a reduction in the production of Mip-2, a chemokine that attracts neutrophils. Mice lacking DNGR-1 do not recognize the tissue injury and therefore do not reduce Mip-2 production. The resulting excess neutrophil infiltration in the kidney results in more extensive, immunopathological tissue damage.

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CNIC

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