IL-31 as Central Mediator of Itch (IMAGE)

University of Zurich

IL-31 as Central Mediator of Itch

Caption

IL-31 as central mediator of itch. Allergens penetrating the skin will trigger mast cells and type II T helper cells. Both cell types will then secrete IL-31, stimulating peripheral sensory nerves, finally signalling itch to the brain. Blocking IL-31 by antibodies will block the itching.

Credit

M. Mohsen / Universität Bern

Usage Restrictions

None

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.