Immune Response to Overwhelming Virus Infection (IMAGE)

Walter and Eliza Hall Institute

Immune Response to Overwhelming Virus Infection

Caption

This graphic shows a typical immune response to overwhelming virus infection, with and without IL-7 treatment. The upper panels show an overwhelming viral infection. Active SOCS-3 dampens the immune response; decreased T cell numbers and impaired function leads to establishment of a chronic viral infection. The lower panels show an overwhelming viral infection with IL-7 treatment. IL-7 represses SOCS-3 and the immune response is reinvigorated. T cell numbers increase and function is enhanced, allowing the immune system to clear the virus.

Credit

Peter Maltezos and Marc Pellegrini, Walter and Eliza Hall Institute

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