Tumor-Derived Organoids (IMAGE) Kanazawa University Caption Tumor-derived organoids were transplanted to mouse spleen (top), and p53 status of the liver metastasized tumor cells were analyzed b PCR (middle). Notably, most metastasized tumor cells lost wild-type p53, suggesting that loss of p53 with GOF mutant p53 accelerates liver metastasis. Credit Kanazawa University Usage Restrictions The image may only be used with appropriate caption and credit. License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.