key roles of two Plasmodium asparyl proteases (IMAGE)

Université de Genève

key roles of two Plasmodium asparyl proteases

Caption

This study identifies the key roles of two Plasmodium asparyl proteases , Plasmepsins IX and X that are crucial for malaria parasites entry and exit from the infected host cells Remarkably, a peptidomimetic inhibitor of theses two proteases exhibits a potent preventive, therapeutic, and transmission-blocking activity against malaria through the mosquitoes. Cette étude révèle le rôle essentiel de deux protéases aspartiques, les plasmepsines IX et X dans l’entrée et la sortie de la cellule hôte des parasites responsables du paludisme. Une molécule inhibant l’activité de ces deux protéases empêche efficacement l’infection mais aussi la prolifération et la transmission via le moustique des parasites responsables de la malaria.

Credit

The picture is modified from Sturm and Hueussler, Med Microbiol Immunol (2007) 196:127-133 and designed by Cygny Malvar.

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