Nanopatterned "Lab-On-A-Chip" Noninvasively Detects Early and Advanced Breast Cancer (3 of 4) (IMAGE)
Caption
The EV-CLUE chip is a multi-layer device constructed by stacking two slabs made of polydimethylsiloxane (PDMS) on a glass slide. The top PDMS slab is microfabricated with a network of pressure/vacuum valves and pump that controls the circuit of eight parallel microreactors engraved on the middle thin PDMS layer. The microreactors and connecting channels are visualized by filling with blue food dye. The bottom glass slide is patterned with nanoparticle structures and coated with antibody to capture extracellular vesicles. This material relates to a paper that appeared in the Jun. 10, 2020, issue of <i>Science Translational Medicine</i>, published by AAAS. The paper, by P. Zhang at University of Kansas in Lawrence, KS; and colleagues was titled, "Molecular and functional extracellular vesicle analysis using nanopatterned microchips monitors tumor progression and metastasis."
Credit
[Credit: Photo by Yong Zeng]
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