Nanoparticles Deliver Cancer Drug to Tackle Sepsis and Stroke-Related Brain Damage (1 of 2) (IMAGE)

American Association for the Advancement of Science (AAAS)

Nanoparticles Deliver Cancer Drug to Tackle Sepsis and Stroke-Related Brain Damage (1 of 2)

Caption

This illustration shows how the researchers' nanoparticles (DOX-hyd-BSA NPs) selectively kill inflammatory neutrophils to prevent them from invading healthy tissue. The nanoparticles carry doxycycline (DOX) molecules that are held inside albumin (BSA) cells using an acid-sensitive (hyd) bond that releases once inside the neutrophil. This material relates to a paper that appeared in the November 6th, 2019, issue of Science Advances, published by AAAS. The paper, by C.Y. Zhang at Washington State University in Spokane, WA, and colleagues was titled, "Nanoparticle-induced neutrophil apoptosis increases survival in sepsis and alleviates neurological damage in stroke."

Credit

[Credit: Zhang <em>et al.</em>, Washington State University]

Usage Restrictions

Please cite the owner of the material when publishing. This material may be freely used by reporters as part of news coverage, with proper attribution. Non-reporters must contact <i>Science</i> for permission.

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.