A schematic diagram of molecular mechanism of nuclear translocation of PD-L1 and its functions. (IMAGE)

Tokyo Medical and Dental University

A schematic diagram of molecular mechanism of nuclear translocation of PD-L1 and its functions.

Caption

A schematic diagram of molecular mechanism underling nuclear translocation of PD-L1 and its contradictory functions in immune response. PD-L1 deacetylated by HDAC2 is translocated into the nucleus via interacting with various key regulatory proteins for endocytosis and nuclear translocation, then transactivates immune responsive in the nucleus to impact tumour sensitivity to PD-1 blockage (the lower left panel with yellow background), as well as controlling various immune checkpoint gene expression to possibly confer resistance to PD-1 blockage treatment (the lower right panel with gray background). Thus, HDAC2 inhibitor will reduce PD-L1 nuclear localization to prevent the emerging resistance to PD-1 blockade treatment.

Credit

Department of Molecular Genetics,TMDU

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