Figure 2 -- Experimental Design (IMAGE)
Caption
(A) Mice were intramuscularly administered BV or CpG followed by an intravenous challenge with malaria sporozoites (Pb-conGFP) at various time intervals (6 h-14 d). A group of mice administered BV were protected. (B) Mice were intravenously injected with Pb-conGFP sporozoites. At 24 after liver-stage development, the mice were administrated with either BV, CpG, or primaquine. Blood-stage parasites were monitored after sporozoite injection. Once parasites appeared in the blood, all mice died. (Results) BV administration before and after sporozoite infection sterilely protected mice, while all mice administrated with CpG or primaquine were died.
Credit
Kanazawa University
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