Model of the Role of TRF1 in Controlling Pluripotency (IMAGE)

Centro Nacional de Investigaciones Oncológicas (CNIO)

Model of the Role of TRF1 in Controlling Pluripotency

Caption

In normal iPS cells (induced pluripotent stem cells) TRF1 is highly expressed, the Polycomb (PRC2) complex (encompassing EDD, EZH2 and Suz12) is weakly bound to the genome and pluripotency genes are expressed. After TRF1 depletion, TERRA increases its expression, this event results in PRC2 recruitment to genes involved in the control of pluripotency and differentiation and establishment of the K27me3 epigenetic mark, altering their expression

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CNIO

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