Figure 1 (IMAGE)

Institute for Basic Science

Figure 1

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Schematic images proposing the importance of coordination of YAP/TAZ activity and p52/RelB activity during lymph nodes' growth and maintenance.Deletion of YAP/TAZ in fibroblastic reticular cells (FRCs) during development impairs their growth and differentiation, compromising the structural organization of lymph nodes (LNs) and transforming FRCs precursors into fat cells (adipocytes). On the contrary, hyperactivation of YAP/TAZ in FRCs during the developmental period severely impairs FRCs' differentiation and maturation, leaving non-functional and fibrotic LNs.

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