Figure 3 (IMAGE)
Caption
Depletion of Yap/Taz transforms FRC precursors into fat cells. These experiments show YAP/TAZ's role in the differentiation of mesenchymal cell to precursor FRC (first stage) and then in the steps that convert precursor FRC to mature FRC (second stage). A and B show representative images and comparison of perilipin (protein found in fat cells, red) within the inguinal lymph nodes (LN, dashed-line) at different development phases, from the left: 8-weeks old mouse, YAP/TAZ depleted at the second stage, LTbR depleted at the second stage, and YAP/TAZ depleted at the first stage mice. C shows representative images of inguinal LN filled with fat cells (red) with YAP/TAZ depleted at the second stage. The entire LN is visible on top and a magnified view of the region within the white dashed box below.
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