A novel model of KDM5A-mediated transcriptional regulation (IMAGE)

Kumamoto University

A novel model of KDM5A-mediated transcriptional regulation

Caption

KDM5A promotes MYC target gene transcription by reducing H3K4me3 to an optimal level. A KDM5 inhibitor induces hyper-H3K4me3, thereby dampening MYC target gene transcription.

Credit

Associate Professor Hiroto Ohguchi

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