Cell's 'Power House' with Mutated Protein (1 of 2) (VIDEO)

Society for Neuroscience

Caption

This pair of time-lapse movies show mitochondria moving along nerve cell fibers. In the first clip, mitochondria with normal mitofusin proteins move quickly along the fiber. In this second clip, mitochondria with a mutant form of mitofusin 2 are smaller and move slowly. This abnormal movement is thought to be the basis for the neurodegenerative disease Charcot-Marie-Tooth type 2A.

Credit

Courtesy, with permission: Misko et al. <i>The Journal of Neuroscience</i> 2010.

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