Salk Institute Shows How DNA Repair Proteins Distinguish DNA Breaks at Cellular and And Viral Genome (IMAGE)

Salk Institute

Salk Institute Shows How DNA Repair Proteins Distinguish DNA Breaks at Cellular and And Viral Genome

Caption

DNA breaks and DNA viruses are ancient and persistent threats to cellular viability. A universal difference between cellular genomes is that they are far larger and have far more proteins called histones than viral genomes. This universal measure is used to distinguish DNA breaks at viral and cellular genomes to determine if a global or localized response is appropriate. This provides an elegant mechanism to neutralize viral replication without jeopardizing cellular viability.

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Salk Institute

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