IL7 Receptor Expression is Regulated Differently in T Cells and Innate Lymphoid Cells (IMAGE)
Caption
In T cells, IL-7 binding to IL-7R leads to the reduction of FOXO1 transcription factor, necessary for the expression of IL-7Ra subunit, by down-regulating foxo1 gene expression and enhancing the degradation of FOXO1 protein through the phosphorylation of FOXO1. However, in innate lymphoid cells, these signaling pathways are not efficiently activated, leading to the sustained expression of IL-7R in the presence of IL-7.
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