mTOR Issues (IMAGE) Arizona State University Caption Hyperactivity of mTOR has been associated with a number of adverse effects and is implicated in the neurodegeneration associated with both Down syndrome and Alzheimer's. Credit Graphic by Shireen Dooling Usage Restrictions Image may only be used with appropriate caption or credit. License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.